resistance to ultraviolet ( UV ) radiation p 210 BCR / ABL kinase regulates nucleotide excision repair
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منابع مشابه
p210 BCR/ABL kinase regulates nucleotide excision repair (NER) and resistance to UV radiation.
Both clinical and experimental evidence illustrate that p190 and p210 BCR/ABL oncogenic tyrosine kinases induce resistance to DNA damage and confer an intrinsic genetic instability. Here, we investigated whether BCR/ABL expression could modulate nucleotide excision repair (NER). We found that ectopic expression of p210 BCR/ABL in murine lymphoid BaF3 cell line inhibited NER activity in vitro, p...
متن کاملp210 BCR/ABL kinase regulates nucleotide excision repair (NER) and resistance to ultraviolet (UV) radiation. Running head: BCR/ABL regulates NER
To whom the correspondence should be addressed: Dr. Dominique Lautier, INSERM UR 563 Institut Claudius Régaud, 20 rue du Pont Saint-Pierre, 31052 Toulouse, France; Phone: (33) 5 61 42 41 73; Fax: (33) 5 61 42 46 06; E-mail: [email protected] ; or Dr. Tomasz Skorski, Center for Biotechnology, Temple University, Bio-Life Sciences Building Room 419, 1900 N. 12 Street, Philadelphia, PA 19122; P...
متن کاملBCR-ABL down-regulates the DNA repair protein DNA-PKcs.
This study demonstrates in both stable and inducible BCR-ABL-expressing hematopoietic cells a down-regulation of the major mammalian DNA repair protein DNA-PKcs by BCR-ABL. Similar results were found in BCR-ABL CD34(+) cells from patients with chronic myelogenous leukemia (CML). DNA-PKcs down-regulation is a proteasome-dependent degradation that requires tyrosine kinase activity and is associat...
متن کاملAlternative excision repair of ultraviolet B- and C-induced DNA damage in dormant and developing spores of Bacillus subtilis.
The nucleotide excision repair (NER) and spore photoproduct lyase DNA repair pathways are major determinants of Bacillus subtilis spore resistance to UV radiation. We report here that a putative ultraviolet (UV) damage endonuclease encoded by ywjD confers protection to developing and dormant spores of B. subtilis against UV DNA damage. In agreement with its predicted function, a His(6)-YwjD rec...
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The Xiphophorus hybrid fish model is an important resource for investigating the genetics and molecular biology of melanoma. Consistent with studies using human melanoma cell lines, the Xiphophorus melanoma cell line PSM, survives the lethal effects of ultraviolet-B radiation (UV-B) radiation much better than a cell line derived from normal fish tissue. In contrast to human melanoma cells, whic...
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تاریخ انتشار 2003